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KMID : 0366220120470020146
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Korean Journal of Hematology
2012 Volume.47 No. 2 p.146 ~ p.149
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Cyclosporine A treatment for relapsed subcutaneous panniculitis-like T-cell lymphoma: a case with long-term follow-up
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Go Se-Il
Lee Won-Sup
Kang Myoung-Hee
Kim In-Suk
Kim Dong-Chul
Lee Jeong-Hee
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Abstract
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Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a distinctive lymphoma characterized by an infiltration of subcutaneous tissue by neoplastic cytotoxic T cells. There was no distinction between TCR alpha/beta phenotype and TCR gamma/delta phenotype, and anthracycline-based chemotherapy was usually used for both. Here, we report a patient with recurrent SPTL who achieved a second long-term complete remission by repeated cyclosporine A (CsA) treatment. From 2000 to 2001, the patient received anthracycline-based combination chemotherapy. However, the treatment did not induce long-term remission. In 2002, he received cyclosporine treatment for about 6 months. This resulted in a 5-year remission that ended in relapse in 2008. He received CsA treatment once again and attained a second long-term remission. This case suggests that re-treatment with CsA can be a good option for relapsed SPTL cases and can result in long-term remission.
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KEYWORD
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Subcutaneous panniculitis-like T-cell lymphoma, Cyclosporine, Treatment outcome
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